Autism may reflect excitation-inhibition imbalance in brain

Stanford Medicine| Wed Aug 02 11:27:10 EDT 2017
Autism may reflect excitation-inhibition imbalance in brain

Deisseroth, who holds the D.H. Chen Professorship, notes that UCSF psychiatrist John Rubenstein and his colleagues, among others, have theorized that an excitation-inhibition imbalance might account for these phenomena. While myriad genetic variations contribute to autism, many of them may do so by impairing, in diverse ways, a single process or a small number of processes necessary for overall healthy brain function, such as a balance between excitatory and inhibitory signaling in key brain ....

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