cGAS detection of micronuclei links DNA damage and inflammatory mechanisms

The University of Edinburgh
Findings may shed light on inflammatory disease and body’s response to cancer: July 2017 Andrew Jackson and colleagues at the MRC Human Genetics Unit, University of Edinburgh, have identified a new mechanism for how damage to the cell’s genetic material can trigger inflammation, setting in motion processes to remove damaged cells and keep tissues healthy. A key molecule called cGAS is known to bind DNA, triggering inflammation. However, un